Table 3. Clinical manifestations of C57BL/6 mice and gerbils induced by LPS.
| Dose (mg/kg) | Clinical observation | Death/total | Time to death (hr) | |
| Mouse | 0a | Normal | 0/10 | ND |
| 3 | Lethargy, diarrhea and spleen volume increase | 10/10 | 36-45 | |
| 5 | Lethargy, diarrhea and spleen volume increase | 10/10 | 15-26 | |
| Gerbil | 0a | Normal | 0/10 | ND |
| 3 | Lethargy, diarrhea and spleen volume increase | 9/10 | 36-49 | |
| 5 | Lethargy, diarrhea and spleen volume increase | 10/10 | 13-27 |
Mouse represented the C57BL/6 mouse.
a
Control, intraperitoneally injected with saline only.
ND, no animal death determined.