Proximity to platform position for home cage/no handling, home cage/handling, playground/no handling and playground/handling groups of WT (A) and R6/2 (B) mice in all MWM sessions, with data from both sexes pooled. Data from handling and no handling groups as well as from both sexes were pooled to compare home cage and playground groups of WT (C) and R6/2 (D) mice. Data from both sexes and all experimental groups were pooled for WT and R6/2 mice (E). Grey shading in C, D indicates period of enrichment. All data shown are means ± s.e.m. Where error bars are not visible, they are obscured by symbols. n.s. non-significant, * p<0.05, ** p<0.01, *** p<0.001.