Table 1. Phenotypic ETV Resistance of HBV Clones.
| Cell Culture | In Vitro Polymerase | In Vitro Polymerase | |
| ETV EC50, nM, Average ± SD (Range)a | ETV-TP IC50, nM, Average ± SD (Range)a | ddGTP IC50, nM, Average ± SD (Range)a | |
| Wildtype b | 3.0±1.5 (1.4–5.2) | 0.5±0.1 (0.4–0.7) | 87.6±8.4 (78.0–92.9) |
| LVDr L180M + M204V c | 30.4±21.6 (10.4–58.6) | 27.1±5.6 (20.9–31.9) | 137.9±10.0 (123.5–148.3) |
| LVDr + T184L d | 738.4±119.4 (654.0–822.8) | 372.9±142.7 (236.4–542.8) | ND |
| LVDr + S202G d | 1,207.3±1,051.6 (463.7–1,950.9) | 258.3±25.5 (222.7–290.8) | 125.1±8.8 (120.0–135.2) |
| LVDr + M250V d | 3,083.6±1,795.8 (1,813.7–4,353.4) | 229.0±49.5 (192–323.9) | 153.7±51.4 (117.3–190.0) |
| LVDr + T184G + S202I e | >4,000 (>4,000) | 636.1±19 (617.2–655.2) | 187.6±6.7 (180.0–192.7) |
a
EC50 and IC50 values represent the mean ± standard deviation (SD) from at least 3 independent experiments.
b
Wildtype values from a single isolate tested in parallel [5], the average ETV EC50 for a panel of 76 wildtype isolates = 3.4±2.0 nM.
c
LVDr values from a single isolate tested in parallel [5], the average ETV EC50 for a panel of 15 LVDr isolates = 31.1±17.5 nM.
d
Values averaged from 2 independent isolates.
e
Values obtained from a single patient isolate [5].