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Generation of eicosanoids from AA and EPA. Metabolism of AA and EPA by the COX and 5-LO pathways leads to the 2,4- or 3,5-series prostanoids and LTs, respectively. The 2,4-series eicosanoids produced from AA promote inflammatory and prothrombotic effects, whereas the corresponding 3,5-series eicosanoids produced from EPA have either the opposite effects or possess much lower levels of biological activity.
