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. 2009 Sep 23;2(3):149–158. doi: 10.1159/000235565

Fig. 1.

Fig. 1

Simplified schematic illustrating potential mechanisms through which ω-3 PUFAs may exert anti-neoplastic effects. a The ω-3 PUFAs EPA and DHA inihibit activity of COX and lipoxygenase enzymes, thus decreasing production of proinflammatory leukotrienes, prostaglandins and thromboxanes. b ω-3 PUFAs alter activity of cyclins and cyclin-dependent kinases, preferentially shifting cells towards apoptosis. c ω-3 PUFAs alter production and activity of various transcription factors, thus influencing protein production and cell division. AA = Arachidonic acid; LA = linoleic acid.