Table 1.
Social separation stress-induced differences in cortical thickness determined by unbiased mesh modeling analysis
| Cluster | Area mm2 | Mean (SEM) cortical thickness mm |
p | |
|---|---|---|---|---|
| intermittent separations | no separations | |||
| L1 | 132.74 | 2.80 (0.02) | 2.64 (0.03) | 0.001 |
| L2 | 358.79 | 2.23 (0.03) | 2.07 (0.03) | 0.001 |
| L3 | 29.07 | 1.82 (0.04) | 1.97 (0.05) | 0.039 |
| L4 | 83.72 | 1.55 (0.04) | 1.34 (0.04) | 0.003 |
| L5 | 50.84 | 1.19 (0.04) | 0.96 (0.07) | 0.010 |
| L6 | 65.32 | 2.23 (0.045) | 2.03 (0.05) | 0.008 |
| L7 | 370.92 | 1.84 (0.03) | 1.68 (0.03) | 0.000 |
| R1 | 61.29 | 2.73 (0.04) | 2.55 (0.05) | 0.009 |
| R2 | 97.42 | 1.90 (0.03) | 2.08 (0.04) | 0.003 |
| R3 | 154.71 | 2.17 (0.03) | 2.06 (0.03) | 0.015 |
| R4 | 286.32 | 1.79 (0.04) | 1.65 (0.03) | 0.004 |
| R5 | 8.08 | 1.61 (0.03) | 1.47 (0.05) | 0.029 |
The area and thickness of all clusters identified as significantly different in monkeys exposed to intermittent separation stress compared to the no-stress condition are presented for each cluster location depicted in figure 2 (n = 9 per condition). Total cortical area of the group-average brain template is 25,200 mm2. Clusterwise cortical thickness group differences were confirmed by MANOVA for the left (clusters L1–L7, Wilks' lambda = 0.125, F(7,10) = 9.973, p = 0.001) and right (clusters R1–R5, Wilks' lambda = 0.335, F(5,12) = 4.757, p = 0.013) hemispheres.