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. Author manuscript; available in PMC: 2011 Feb 2.
Published in final edited form as: Mol Cancer Ther. 2010 Feb 2;9(2):268. doi: 10.1158/1535-7163.MCT-09-0765

Figure 3.

Figure 3

Schematic representation of AURKA interactions. AURKA over-expression inhibits p53 family members and suppresses apoptosis and cell cycle arrest. AURKA interacts directly with p53 by phosphorylating it at Ser215 (34) and 315 (35) causing its degradation through MDM2 or inactivating it at transcription level, respectively. AURKA regulates p73 and its downstream targets (37). It also up-regulates the PI3 kinase pathway that enhances cell survival and proliferation either directly interacting with GSK-3β (41) or by regulating AKT (36, 75).