Table 1.

Aurora kinase inhibitors in clinical trials^*

Inhibitor	AURKA inhibition	AURKB inhibition	AURKC inhibition	Manufacturer	Clinical Status
AZD1152	+	+	−	Astra Zeneca	Phase I
VX-680	+	+	+	Vertex/Merck	Discontinued
MLN8054	+	+	−	Millinnium	Discontinued
MLN8237	+	+	−	Millinnium	Phase II
PHA-680632	+	+		Nerviano	Preclinical
PHA-739358	+	+	+	Nerviano	Phase II
Hesperidin	−	+	−	Boehringer-Ingelhiem	Preclinical
ZM447439	+	+	−	Astra Zeneca	Phase I
JNJ-770621	+	+	−	Johnson & Johnson	Preclinical
SU6668	+	+	−	Pfizer	Discontinued
CCT129202	+	+	+	Chroma Therapeutics Ltd.	Preclinical
AT9283	+	+	−	Astrex Therapeutics	Phase I
MP529	+	+	−	Supregen	Preclinical
SNS314	+	+	+	Sunesis Pharmaceuticals	Phase I
R763	−	+	−	Rigel Pharmaceuticals	Phase I
ENMD2076	+	+	−	EntreMed	Phase I
XL228	+	+	+	Exelixis	Phase I
TTP607	+	+	+	TransTech Pharma	Phase I
PF-03814735	+	+	−	Pfizer	Phase I
CYC116	+	+	+	Cyclacel	Phase I