Table 1.
Genes up-regulated in response to IL-29 Guenterberg et al.
| Time (Hr) | 5 | 5 | 18 | 18 | |
|---|---|---|---|---|---|
| IL-29 Dose (ng/ml) | 10 | 1000 | 10 | 1000 | |
| Gene | Function | Fold Change | |||
| IFI27 | Immune response | - | 32 | 168.9 | 415.9 |
| RSAD2 | Viral Response | 21.1 | 48.5 | 19.7 | 84.4 |
| DMGDH | Electron Transport, Glycine Catabolic Process | - | - | - | 73.5 |
| IFI44L | Unknown | 7.5 | 11.3 | 34.3 | 64 |
| IFIT1 | Immune response | 22.6 | 48.5 | 32 | 64 |
| OAS2 | Immune response, nucleic acid metabolism | 5.3 | 11.3 | 27.9 | 64 |
| MX1 | Regulation of Apoptosis, immune response | 7.5 | 12.1 | 27.9 | 52 |
| EPSTI1 | Unknown | 2.8 | 6.1 | 21.1 | 42.2 |
| OAS1 | Antiviral response, nucleosidase | 5.7 | 9.2 | 15 | 32 |
| DDX58 | Helicase, Deoxyribonuclease, Ubiquitin Pathway | 5.3 | 11.3 | 10.6 | 26 |
| ISG15 | Immune response | 3 | 5.7 | 13 | 26 |
| IFI6 | Regulator of Apoptosis, immune response | 3.5 | 5.3 | 14.9 | 21.1 |
| IFIT3 | Immune response | 4.3 | 7.4 | 8 | 19.7 |
| IFITM1 | Immune response, negative regulation of proliferation | 2.3 | 3.5 | 10.6 | 19.7 |
| PRIC285 | Regulation of transcription | 4 | 8.6 | 10.6 | 18.4 |
| SULT1C2 | Amine Metabolic Process | - | - | - | 18.4 |
| OASL | Immune response, nucleic acid metabolism | - | 4.6 | 5.3 | 16 |
| XAF1 | Zinc Ion Binding | 4.6 | 11.3 | 7 | 16 |
| TMPRSS3 | Proteolysis, Sensory Reception | - | - | 18.4 | 15 |
| LOC129607 | dTDP/dTTP biosynthetic process | 2.3 | 4 | 5.3 | 13 |
| IFIH1 | Helicase, Deoxyribonuclease | 2.8 | 5.3 | 4.9 | 12.1 |
| HFE2 | GPI Anchor Binding | - | - | - | 11.3 |
| RTP4 | Sensory Reception | - | 3.2 | 5.7 | 11.3 |
| SAMD9L | Unknown | 5.3 | 6.1 | 5.3 | 11.3 |
| PARP9 | Protein ADP Ribosylation, Cell Migration | 3 | 4.3 | 6.1 | 10.6 |
| CCNC | Cell Cycle Regulation | - | - | - | 9.8 |
| IFIT2 | Immune response | - | 3.7 | 3.5 | 9.8 |
| TLX2 | Regulation of Transcription, Negative Regulation of Dendrite Morphogenesis | - | - | - | 9.8 |
| FLJ20035 | Nucleic Acid Binding, Helicase Activity | 2 | 2.5 | 5.7 | 9.2 |
| IRF9 | Regulation of Transcription, Immune Response, Viral Response | 5.7 | 7.5 | 8 | 9.2 |
| STAT1 | Transcription factor, JAK-STAT pathway | 2.6 | 3.5 | 5.3 | 9.2 |
| ACOT11 | Intracellular Signaling Cascade, Response to Temperature Stimulus | - | - | - | 8.6 |
| HERC5 | Regulation of cyclin dependent protein kinase activity, Ubiquitin Pathway | - | 2.3 | 3.5 | 8.6 |
| IRF7 | Transcription factor, antiviral response, Apoptosis | 2.5 | 3.2 | 4.6 | 8.6 |
| TRIM22 | Regulation of Transcription, Immune Response, Response to Virus | - | 2.3 | 3 | 8.6 |
| USP18 | Ubiquitin-dependent protein catabolism | - | 3 | 4 | 8.6 |
| FAM125A | Unknown | - | 2.3 | 4.3 | 7.5 |
| HERC6 | Ubiquitin-protein ligase | - | 2.8 | 4.9 | 7.5 |
| HTRA4 | Proteolysis | - | - | - | 7 |
| IFI44 | Antiviral response | 2.1 | 4.9 | 4.3 | 7 |
| OAS3 | Immune response, nucleosidase | - | 2.6 | 4.6 | 7 |
| LOC646756 | Unknown | - | - | - | 6.5 |
| LBA1 | DNA Repair | - | - | 3 | 6.1 |
| BATF2 | Regualtion of Transcription | - | 2.6 | 2.8 | 5.7 |
| TIPARP | Protein AA ADP-Ribosylation | - | - | - | 5.7 |
| PARP14 | regulation of transcription | - | 2.6 | 3 | 5.3 |
| PLSCR1 | Phospholipid scramblase, platelet activation | 2 | 2.8 | 3.5 | 5.3 |
| SAMHD1 | Immune response | - | 2 | 10.6 | 5.3 |
| SAMD9 | Unknown | 2 | 2.5 | 2.6 | 4.9 |
| ZPLD1 | Unknown | - | - | - | 4.9 |
| BST2 | Immune response, cell-cell signaling, cell proliferation, regulator of I-kappaB kinase/NF-kappa B caspase | - | - | 2.8 | 4.6 |
| SP110 | Regulation of transcription, transcription factor | - | 2 | 2.8 | 4.6 |
| DTX3L | Protein bining | - | 2.5 | 3 | 4.3 |
| CTCFL | Negative regulation of cell cycle progression | - | - | - | 4 |
| CXCL10 | Chemotaxis, monocyte stimulation | - | - | - | 4 |
| DCDC2 | Neuron migration, cellular defense, intracellular signaling | - | - | - | 4 |
| FBN2 | Embryonic/anatomic limb morphogenesis | - | - | - | 4 |
| PARP12 | Protein amino acid ADP-ribosylation | - | - | 2.6 | 4 |
| RNF103 | CNS development | - | - | - | 4 |