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. Author manuscript; available in PMC: 2011 Feb 2.
Published in final edited form as: Mol Cancer Ther. 2010 Feb 2;9(2):438. doi: 10.1158/1535-7163.MCT-09-0682

Figure 1. α-mTer-siRNA knocks down WT-mTer and inhibits telomerase activity in E4 mouse prostate cancer cells.

Figure 1

(A) α-mTer-siRNA structure and cloning into lentiviral vector system (target sequence is boxed, template region is underlined). (B) α-mTer-siRNA knocks down WT-mTer by 80% three days after expression in E4 cells, as quantified by real-time PCR (RT-PCR). (C) α-mTer-siRNA inhibits telomerase activity by 95% three days after expression in E4 cells, as quantified by real-time PCR telomeric repeat amplification protocol.