Table.

Adjusted sex odds ratios and percentage of boys as function of severe life events before and in periconceptional period and stratified for timing of exposure

Type of cohort	Numbers	Boys (%)	Sex odds ratio (95% confidence interval)*
Controls	20 337	51.2	1.00
Exposed women:	3 072	49.0	0.91 (0.84 to 0.99)
Exposed 13-16 months before†	71	52.1	1.04 (0.65 to 1.69)
Exposed 7-12 months before†	789	49.6	0.94 (0.81 to 1.08)
Exposed 0-6 months before†	1 922	48.9	0.91 (0.83 to 1.01)
Exposed first trimester	290	46.0	0.81 (0.64 to 1.02)
Source of exposure:
Older sibling:	2 661	49.4	0.93 (0.85 to 1.01)
Exposed 13-16 months before†	56	55.4	1.18 (0.70 to 2.00)
Exposed 7-12 months before†	693	50.8	0.98 (0.84 to 1.15)
Exposed 0-6 months before†	1 771	49.1	0.92 (0.83 to 1.02)
Exposed first trimester	141	43.6	0.74 (0.53 to 1.03)
Partners	411	46.5	0.83 (0.68 to 1.01)
Type of life event:
Death	2 575	49.0	0.92 (0.84 to 1.00)
Exposed 13-16 months before†	44	54.7	1.15 (0.63 to 2.08)
Exposed 7-12 months before†	650	50.5	0.97 (0.83 to 1.14)
Exposed 0-6 months before†	1 718	49.2	0.92 (0.83 to 1.02)
Exposed first trimester	163	40.6	0.65 (0.47 to 0.89)
Cancer	426	48.1	0.88 (0.73 to 1.07)
Acute myocardial infarction	71	49.6	0.94 (0.59 to 1.59)

^*Sex ratio of exposed/sex ratio of non-exposed; and adjusted for maternal and partners’ ages as well as for school education, maternal parity (nulliparous v multiparous), previous spontaneous abortions (yes/no), residence (capital, major city, or rural), and congenital malformation in offspring (yes/no). 

^†Before first day of last menstruation.