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a Concentration-dependent relaxant effects of hydroxyfasudil in chicken embryo femoral arteries contracted with KCl (125 mM) or PE (10 μM). The effects of the NOS inhibitor l-NAME (100 μM) and the sGC inhibitor ODQ (10 μM) are also shown (only in KCl-contracted arteries). *P < 0.05 vs control for difference in E max. b, c Incubation under chronic hypoxia (15% O2 from day 0) did not affect hydroxyfasudil-induced relaxation of (b) KCl- or (c) PE-contracted arteries
