Table 3.
Prognostic factors for survival and local recurrence of disease: univariate Cox regression analysis
| Factor | Hazard ratio | 95% Confidential interval | P value | |
|---|---|---|---|---|
| Lower | Upper | |||
| Survival | ||||
| Tumor grade | 1.001 | 0.654 | 1.532 | 0.997 |
| Type of growth | 0.824 | 0.446 | 1.525 | 0.539 |
| Perineural invasion | 1.636 | 0.847 | 3.160 | 0.143 |
| Lymph vascular space involvement | 1.984 | 1.082 | 3.639 | 0.027 |
| Stage | ||||
| pT stage | 1.338 | 1.048 | 1.707 | 0.019 |
| pN stage | 5.344 | 2.548 | 11.209 | <0.001 |
| pM1a stage | 3.951 | 1.202 | 12.986 | 0.024 |
| CRM in mm | 0.762 | 0.630 | 0.921 | 0.005 |
| CRM ingrowth (0 mm) | 0.357 | 0.193 | 0.659 | 0.001 |
| Recurrent disease | 9.768 | 4.427 | 21.631 | <0.001 |
| >4 positive lymph nodes | 4.904 | 2.520 | 9.564 | <0.001 |
| Lymph node ratio >0.20 | 3.987 | 2.164 | 7.346 | <0.001 |
| Tumor length (cm) | 1.120 | 1.006 | 1.248 | 0.039 |
| Local recurrence | ||||
| Tumor grade | 0.967 | 0.632 | 1.479 | 0.876 |
| Type of growth | 0.812 | 0.441 | 1.496 | 0.504 |
| Perineural invasion | 2.620 | 1.429 | 4.802 | 0.002 |
| Lymph vascular space involvement | 2.412 | 1.327 | 4.383 | 0.004 |
| Stage | ||||
| pT stage | 1.304 | 1.025 | 1.660 | 0.031 |
| pN stage | 5.357 | 2.634 | 10.859 | <0.001 |
| pM1a stage | 2.709 | 0.646 | 11.367 | 0.173 |
| CRM in mm | 0.754 | 0.623 | 0.913 | 0.004 |
| CRM ingrowth (0 mm) | 0.358 | 0.198 | 0.648 | 0.001 |
| >4 positive lymph nodes | 6.276 | 3.299 | 11.937 | <0.001 |
| Lymph node ratio >0.20 | 5.237 | 2.883 | 9.514 | <0.001 |
| Tumor length (cm) | 1.157 | 1.044 | 1.282 | 0.005 |