Table 3.

Significant group differences in fMRI activity associated with successful encoding and retrieval within the MTL and PFC

			Coordinates
	H	BA	x	y	z	T	Voxels
met/met > val/vala
ESA
Hippocampus/PHG	L		−15	−12	−22	3.27	12
RSA
Hippocampus/PHG	L		−19	−30	−11	3.84	32
PHG	L	28/36	−23	−9	−28	2.57	10
	R	28/34	26	−5	−29	3.64	26
PHG	R	36	41	−19	−12	3.43	10
Ventromedial PFC	L	47/11	−23	25	−14	3.13	33
	R	47	15	7	−13	3.92	23
val/val > met/metb
ESA
Dorsolateral PFC	L	46/9/10	−19	41	15	4.59	116
	R	46/9	38	16	24	3.14	35
Superior PFC	L	8	−8	32	44	2.43	23
Motor/premotor	R	6/9	26	−5	39	3.82	30
	R	6/4	45	−5	39	3.2	29
	R	6	8	11	62	2.51	15
RSA
Dorsolateral PFC	R	45	30	23	16	2.53	25
	R	44/45	45	19	10	2.51	16
Superior PFC	L	8/6	−38	10	45	3.56	36
	L	8	−11	−20	50	3.16	29
	L	9	−11	42	29	2.29	13
Frontopolar cortex	R	10	11	55	−6	2.47	19
Motor/premotor	L	6/4	−11	28	48	3.2	31
	R	6/4	11	−30	65	3.07	17

^aRegions within the MTL and PFC where individuals homozygous for the met allele showed increased ESA and RSA compared with individual homogygous for the val allele.

^bRegions within the MTL and PFC where individuals homozygous for the val allele showed increased ESA and RSA compared with individual homogygous for the met allele. Results include all significant group differences within the MTL and PFC significant at P < 0.05, k > 10 voxels masked with the effects of interest at P < 0.05, k > 10 voxels (conjoint probability P < 0.0025). H: hemisphere; BA: Brodmann's area.