Table 4.

Group differences in MTL connectivity associated with both encoding and retrieval success in 22 healthy participants

	H	BA	x	y	z	T	Voxels
met/met > val/vala
ESA
^Orbitofrontal cortex	L	11	−11	47	−18	4.02	50
^Superior PFC	R	6	11	11	66	3.43	43
^ACC	R	24/32	15	16	27	3.24	41
^Dorsolateral PFC	R	10/46	41	41	12	3.28	30
^Sensorimotor cortex	L	4/6	−26	−9	46	3.61	85
Insula	R	13	38	−7	14	3.59	79
Superior temporal gyrus	R	21/22	56	−44	−1	5.28	93
Temporal–parietal junction	L	40/37/22/20	−38	−43	16	4.43	210
RSA
^Dorsomedial PFC	R	9/46	26	38	23	2.9	103
Putamen	R		23	22	2	3.68	30
^ACC	R	24	19	29	−5	3.42	(10)
Parietofrontal cortex	R	40/7/39/31	30	−54	31	5.49	506
^Superior PFC	R	8/6	45	10	49	3.28	(71)
Thalamus	R		19	−19	−5	2.97	50
*Anterior PHG	R	34	11	−8	−19	2.27	(8)
Retrosplenial cortex	M	23	0	−28	22	3.54	44
Occipital cortex	R	18/19	23	−85	8	3.21	38
Cerebellum	R		23	−31	−30	2.85	34
val/val>met/metb
ESA
Occipitotemporal cortex	L	17/18/27/30	−11	−33	−2	4.68	262
*PHG	L	27/30	−19	−37	−8	4.17	(18)
Posterior cingulate/occipital cortex	L	18/19/20/30/35	−11	−36	23	3.38	204
*PHG	R	35	19	−30	−11	2.84	(13)
Anterior temporal cortex	R	28/34/38	26	10	−23	4.57	67
*Rhinal cortex	R	28/34	23	−5	−19	3.23	(18)
Anterior temporal cortex	L	38/28/20	−41	5	−39	3.16	41
*Rhinal cortex	L	38/20	−26	−1	−22	2.26	(6)
ACC	R	32/10	11	45	12	3.19	47
Caudate	L		−23	14	−7	2.63	32
Occipitoparietal cortex	R	40013	15	−53	45	4.06	78
Cerebellum	M		0	−50	−33	3.98	84
RSA
*PHG/HC	L	27/35	−19	−26	−2	3.89	34
Superior/middle temporal gyrus	R	22/42	49	−25	15	4.31	186
*Rhinal cortex/PHG	R	34	30	7	−16	3.54	(9)
Superior temporal gyrus	L	29	−41	−32	16	3.09	96
*Rhinal cortex/PHG	L	34	−30	−4	−13	1.87	(4)
Orbitofrontal cortex	L	10/9	−8	63	7	3.44	59
Posterior cingulate	L	31	−11	−66	14	4.55	61
Inferior parietal cortex	L	3	−56	−20	40	3.26	45
Cerebellum	L		−11	−64	−32	3.99	383

^aBrain regions exhibiting greater MTL connectivity during encoding and retrieval for individuals homozygous for the met allele compared with individual honogygous for the val allele.

^bBrain regions exhibiting greater MTL connectivity during encoding and retrieval for individuals homozygous for the val allele compared with individual honogygous for the met allele. Results include all significant group differences within the MTL and PFC significant at P < 0.05, with a minimum cluster size > 30 voxels. ESA: encoding success activity; RSA: retrieval success activity; PHG: parahippocampal gyrus; PFC: prefrontal cortex; ACC: anterior cingulate cortex; H: hemisphere; BA: Brodmann's area; ^highlights PFC regions; *highlights MTL regions; brackets () indicate the voxel extent of the subpeaks, which are identified through the use of indentations in the table.