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. 2009 Dec 17;285(8):5137–5145. doi: 10.1074/jbc.M109.064691

FIGURE 2.

FIGURE 2.

Sequence alignment of DH-PH domains of human RhoGEFs. PDZ-RhoGEF (O15085, residues 734–923), LARG (Q9NZN5, residues 787–977), p115-RhoGEF (Q92888, residues 416–605), Dbl-GEF (Q92974,, residues 235–432), p63-RhoGEF (Q86VW2, residues 160–336), Dbs-GEF (O15068, residues 631–811), and Tiam1 (Q13009, residues 1,040–1,234) were aligned using Clustal_W2. Hydrophobic, acidic, basic, and polar residues are indicated in red, blue, magenta, and green, respectively. The stars mark residues conserved throughout Rho guanine nucleotide exchange factors. Colons correspond to conserved substitutions and, periods correspond to semiconserved substitutions. Conserved residues examined in this study (Glu-741, Arg-868, and Ser-1065) are boxed. CR1, CR2, and CR3 are three highly conserved regions of the DH domain.