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PDZ-RhoGEF preferentially catalyzes nucleotide exchange in the direction of activation (GDP to GTPγS). Plots of the nucleotide exchange for RhoA-GDP to GTPγS (circles) and RhoA-GTPγS to GDP (triangles) (intrinsic, open; GEF-mediated, filled) are shown. A 5-fold molar excess of GTPγS was added to 15N-labeled RhoA-GDP, and a 50-fold molar excess of GDP was added to 15N-labeled RhoA-GTPγS. Error bars indicate S.D. for values reported by multiple peaks.
