TABLE 2.

Biochemical characteristics of F. tularensis acid phosphatases inhibitors

Enzyme	Small molecule	Kia	Interaction
		μm
AcpA
	Ascorbic acid	380.0 ± 160	NCb
	(+)-5,6-O-Isopropylidene-l-ascorbic acid	3.27 ± 0.85	NC
	2-Phospho-l-ascorbic acid	0.32 ± 0.16	NC
	2-Sulfate-l-ascorbic	NDc
	6-Palmitate-l-ascorbic	ND
AcpB	Thonzonium bromide	0.59 ± 0.23	Cd
	Procainamide hydrochloride	14.8 ± 3.4	C
AcpC	Atracurium besylate	342.0 ± 50	C
	Myricetin	154.0 ± 89	C
	Kaempferol	190.0 ± 30	C

^a Calculated from at least three independent determinations using different concentration of inhibitors.

^b NC, no competitive interaction.

^c ND, inhibition was not detected.

^d C, competitive interaction.