TABLE 3.

Influence of ITPKA expression on formation of metastasis

H1299 control and H1299 cells stably overexpressing ITPKA (H1299-ITPKA) were injected subcutaneously in SCID mice. After 6 weeks, the first tumors had formed. When the primary tumors were about the same size, the mice were sacrificed, and the weight of the primary tumor and the number of lung metastases were determined. The mean ± S.E. of tumor weights and the number of metastases detected in lungs from 9 to 10 mice are shown.

Cell line	Tumour weight, in grams, mean ± S.E	No. of metastases, mean ± S.E.
H1299 control	3.93 ± 0.7	24 ± 5.9
H1299-ITPKA	4.33 ± 0.5	89 ± 20
	p < 0.53	p < 0.005