Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 Dec 18;285(8):5555–5568. doi: 10.1074/jbc.M109.074740

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

FIGURE 10. — Intracellular and in vitro degradation of ACE. A, SMC preincubated with ¹²⁵I-ACE displayed the pattern of large (100 to 70 kDa) and small (5.0 to 1.0 kDa) fragments. Pretreatment of the cells with pepstatin A partially prevented generation of small fragments. The asterisk indicates a 5.0-kDa fragment that is absent when cells are pretreated with pepstatin A. Arrows indicate the observed fragments. B, a time course incubation of ¹²⁵I-ACE with cathepsin D also revealed the production of several fragments.