Figure 2. IL-17A plasma levels.
IL-17A plasma levels were determined using ELISA. As a control for the assay, media levels of IL-17A produced by peripheral blood mononuclear cells (PBMCs) from two healthy donors (PBMC1, PBMC2) after stimulation by PMA and ionomycin were used. A plasma sample from a patient with active JIA was also used as a positive control. The “LCH” number corresponds to the patient descriptions in Table 1. Group 1–3 correspond to clinical categories defined by the Histiocyte Society LCH-III protocol. Group 4 includes patients with single non-risk lesions.