FIG. 6.

Functional deletion of the M. tuberculosis RelE homologs confers decreased persistence to specific drugs. Early-log-phase cultures were diluted to an OD₆₅₀ of 0.01 to 0.02 and treated with Rif (4 μg/ml), Gm (10 μg/ml), Levo (10 μg/ml), or INH (1 μg/ml) for 7 days at 37°C, followed by CFU analysis. CFU enumeration and percent survival were calculated as described in the legend for Fig. 5. The results shown are from one of three independent experiments.