TABLE I.
Baseline Clinical Characteristics by Post-PCI MPG
| Post-PCI MPG 0 to 1, N = 60 |
Post-PCI MPG 2 to 3, N = 201 |
P value | |
|---|---|---|---|
| Male, % | 81.7 | 78.1 | 0.55 |
| Age yrs, mean (SD) | 54.6 (9.1) | 57.3 (10.8) | 0.08 |
| Diabetes, % | 18.3 | 16.9 | 0.80 |
| Hypertension, % | 48.3 | 51.2 | 0.69 |
| Hyperlipidemia, % | 43.3 | 60.2 | 0.02 |
| Family history of CAD, % | 40.0 | 43.3 | 0.65 |
| Current smoker, % | 45.0 | 36.3 | 0.22 |
| Prior angina, % | 18.3 | 17.4 | 0.87 |
| Prior MI, % | 8.3 | 9.4 | 0.79 |
| Interval from MI to baseline angiogram (days), median (IQR) | 5 (4, 9.5) | 6 (3, 11) | 0.50 |
| Interval from MI to randomization (days), median (IQR) | 9 (5, 17) | 10 (6, 20) | 0.25 |
| Interval from MI to PCI (days), median (IQR) | 10 (6, 19.5) | 11 (7, 21) | 0.25 |
| Interval from baseline angiogram to PCI (days), median (IQR) | 2 (1, 7) | 2 (0, 7) | 0.92 |
| Heart rate beats/min, mean (SD) | 74.3 (12.6) | 68.3 (10.4) | 0.001 |
| Systolic blood pressure mm Hg, mean (SD) | 112.4 (16.6) | 119.1 (15.1) | 0.003 |
| Diastolic blood pressure mm Hg, mean (SD) | 69.3 (11.8) | 72.5 (10.1) | 0.04 |
| Fibrinolytic therapy during first 24 hr of index MI (%) | 31.7 | 15.4 | 0.005 |
| ST elevation >0.1mV, % | 78.3 | 61.4 | 0.02 |
| ST depression > 0.1 mV, % | 73.3 | 71.4 | 0.77 |
| Maximum pre-PCI Total CK divided by ULN, mean (SD) | 9.2 (6.0) | 7.0 (7.6) | 0.07 |
| Maximum pre-PCI CK MB divided by ULN, mean (SD) | 18.3 (22.0) | 10.6 (13.4) | 0.05 |
| Maximum pre-PCI TNI divided by ULN, mean (SD) | 284.0 (493.5) | 241.2 (605.7) | 0.71 |
| Maximum pre-PCI TNT divided by ULN, mean (SD) | 159.6 (160.8) | 51.4 (68.0) | 0.05 |
| Killip Class > 1 during index MI,% | 10.0 | 14.4 | 0.38 |
| NYHA Class > 1 at randomization,% | 8.3 | 11.0 | 0.56 |
| Presence of ischemia in IRA territory on pre-PCI stress testing, N (%) | 8/19 (42.1%) | 23/62 (37.1%) | 0.69 |
PCI, percutaneous coronary intervention; MPG, myocardial perfusion grade; SD, standard deviation; CAD, coronary artery disease; MI, myocardial infarction; IQR, interquartile range; ULN, upper limit of the local laboratory normal; CK, creatine kinase; TNI, troponin I; TNT, troponin T.