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Depletion of RRP36 mRNA in HeLa cells affects the production of the mature 18S rRNA. Neosynthesized RNAs from HeLa cells transfected with siRNAs targeting RRP36 mRNA (lanes 7 to 12) or mock transfected (lanes 1 to 6) were pulse-labeled with l-methyl 3H methionine 48 h posttransfection. Cells were subsequently rinsed to remove radioactive methionine, incubated in regular DMEM, and harvested at the indicated time points. The different (pre-)rRNA species are indicated on the left.
