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Positions of the phosphorylation site mutations. Shown is a schematic representation of the ICP27 coding sequence illustrating the leucine-rich region (LRR) at the N terminus with CK2 sites denoted; the nuclear localization signal (NLS) with the PKA site denoted; the RGG box RNA binding domain; three predicted KH domains; and a zinc-finger-like region (CCHC). The mutant viruses are listed along with the affected domain and the amino acid substitution.
