TABLE 2.
Breadth of neutralizing antibody responses of immunized rabbits
| Pseudovirus testeda | Subtype | IC50b |
||||
|---|---|---|---|---|---|---|
| Kenya poolc | Q461d1S immunizedd | Q461e2R immunizedd | Q168b23S immunizedd | Q168a2R immunizedd | ||
| Q769b9 | A | <50 | <20 | <20 | <20 | <20 |
| QF495.23 M.ENV.A1 | A | 100 | <20 | <20 | <20 | <20 |
| Q842d16 | A | 135 | <20 | <20 | <20 | <20 |
| BJ613.E1 | A | 142 | <20 | <20 | <20 | <20 |
| BS208.B1 | A | 207 | <20 | <20 | <20 | <20 |
| BF535.A1 | A/D | 76 | <20 | <20 | <20 | <20 |
| QA790.204I.ENV.C1 | A/D | 148 | <20 | <20 | <20 | <20 |
| THRO4156.18 | B | 52 | <20 | <20 | <20 | <20 |
| 6434.4 | B | 106 | <20 | <20 | <20 | <20 |
| QB099.227 M.ENV.C8 | C | 108 | <20 | <20 | <20 | <20 |
| QC406.70 M.ENV.F3 | C | 119 | <20 | <20 | <20 | <20 |
| Du156.12 | C | 137 | <20 | <20 | <20 | <20 |
| QA465.59 M.ENV.D1 | D | <50 | <20 | <20 | <20 | <20 |
| QD435.100 M.ENV.A4 | D | 69 | <20 | <20 | <20 | <20 |
a
The pseudoviruses used to assess neutralization breadth have been described previously (6, 41, 42).
b
The IC50 value is defined as the reciprocal dilution of sera which mediates 50% neutralization; <20 indicates that <50% neutralization was observed with a 1:20 dilution of plasma.
c
The Kenya pool was derived by pooling plasma from 30 HIV-1-infected individuals in Kenya as previously described (6).
d
Each of six animals in each immunization group was tested individually.