TABLE 1.
Demographic, immunologic, virologic, and genetic features of African Americans in the individual and combined REACH (1996-2001) and HERS (1993-2000) cohorts
| Variable | Value |
||
|---|---|---|---|
| REACH cohort | HERS cohort | Combined cohorts | |
| Age (yr) (median [range])a | 18 (13-21) | 35 (21-54) | 25 (13-54) |
| Gender (% females)a | 81 | 100 | 91 |
| No. of CD4+ T cells/ml (median [range]) | 477 (0-1,461) | 475 (11-1,416) | 476 (0-1,461) |
| Viral load (log10 copies/ml) (median [range])a | 3.8 (1.0c-6.7) | 3.5 (1.4-5.6) | 3.6 (1-6.7) |
| HLA class I supertypes (n [% of patients with supertype])b | |||
| A1s | 29 (9) | 37 (11) | 66 (10) |
| A2s | 78 (24) | 83 (24) | 161 (24) |
| A24s | 89 (28) | 103 (29) | 192 (28) |
| A3s | 126 (39) | 131 (37) | 257 (38) |
| B7s | 146 (45) | 152 (43) | 298 (44) |
| B27s | 56 (17) | 56 (16) | 112 (16) |
| B44s | 70 (22) | 69 (20) | 139 (21) |
| B58s | 45 (14) | 68 (19) | 113 (17) |
| B62s | 5 (2) | 9 (2) | 14 (2) |
a
P < 0.05 for differences in between the individual cohorts.
b
HLA-A and -B supertype distributions are based on their population (2N) frequencies.
c
Corresponding to 1/2 log10VL for plasma HIV-1 RNA level of <80 copies/ml.