TABLE 4.

Factors associated with HIV-1 load heterogeneity across genotypic supertypes among African Americans from the REACH (1996-2001) and HERS (1993-2000) cohorts^a

HLA class I marker	Intercept	VL variationc (%)
Baseline modelb	0.126
Level 2 markers
B7s	0.107	15
B27s	0.139	−10
B44s	0.094	25
B58s	0.059	53
B62s	0.114	10
Level 1 markers
B*14	0.117	7
B*1510	0.139	−10
B*35	0.12	5
B*45	0.116	8
B*53	0.117	7
B*57	0.069	45
Infrequent HLA-B allelesd	0.115	9

^aAll estimates were derived from random-effect multilevel models.

^bAdjusted for individual cohort.

^cCorresponding to percentage of explainable log₁₀ VL variation and quantified as the percent difference in variation of VL attributed to each HLA marker included in the model [(baseline intercept − intercept) × 100/baseline intercept], with positive values indicating a decrease and negative values indicating an increase in VL variation (e.g., B27s or B*1510).

^dBased on HLA-B population frequency distribution below the median (4.4%).