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. 2009 Dec 23;84(5):2318–2330. doi: 10.1128/JVI.01097-09

FIG. 4.

FIG. 4.

Localization of MeCP2 to chromocenters is specified by multiple domains. (A) Domain structures of human MeCP2 and the truncation proteins used in this study. (B) The MBD is required for localization of MeCP2 to chromocenters. Representative NIH 3T3 cells expressing each of the DsRed-MeCP2 derivatives are shown. The abilities of MeCP2 derivatives to localize (+) the DsRed signal to chromocenters (foci) are summarized in panel A. (C) Immunoblot analyzed using anti-DsRed antibody to detect expression of DsRed-MeCP2 fusion proteins in the cell extracts.