Table 1.
Calculated concentrations (mM) required to inhibit lipid and protein oxidation by a 50% (IC50) in preventing lipid and protein oxidation in synaptosomal membranes exposed to FeCl3 and ascorbic acid.
| Substance (n = 6) | Lipid peroxidation | Protein oxidation |
|---|---|---|
| Tryptophan | - | 2.92 |
| 5-Hydroxytryptophan | 3.05 | 1.01 |
| 5-Methoxytryptamine | 0.31 | 3.40 |
| N-acetylserotonin | 0.42 | 0.65 |
| Tryptamine | 0.84 | 3.96 |
| Melatonin | 1.75 | 1.40 |
| 5-Methoxy-3-indoleacetic acid | - | - |
| 5-Methoxytryptophol | 1.75 | 0.76 |
| Tryptoline | 1.49 | 0.63 |
| Pinoline | 0.15 | 0.25 |