Table 2.

Mediational analyses predicting major depressive episode at follow-up¹

Predictor	Path	β	F	OR (95% CI)	Comparable β (SE)^a
Left hippocampal vol.
Major depressive episode
Early-life adversity	C	0.64^*	5.74	1.89 (1.12–3.19)	0.33 (0.14)
Hippocampal volume
Early-life adversity	A	−0.37^**	3.05	0.37 (0.13–0.62)	−0.20 (0.06)
Major depressive episode
Early-life adversity	C′	0.38	1.95	1.46 (0.86–2.47)	0.18 (0.13)
Hippocampal volume	B	−0.83^*	5.24	0.44 (0.22–0.89)	−0.40 (0.17)
Right hippocampal vol.
Major depressive episode
Early-life adversity	C	0.64^*	5.74	1.89 (1.12–3.19)	0.33 (0.14)
Hippocampal volume
Early-life adversity	A	−0.41^***	3.38	0.41 (0.17–0.65)	−0.22 (0.06)
Major depressive episode
Early-life adversity	C′	0.41	2.23	1.51(0.88–2.58)	0.20 (0.14)
Hippocampal volume	B	−0.68^*	4.38	0.51 (0.27–0.96)	−0.33 (0.16)

Age, gender, ethnicity/race, pubertal status and socioeconomic status served as covariates in the analyses.

β = beta; OR = odds-ratio; CI = confidence interval; SE = standard error.

C = total effects of early-life adversity on depression; A = effect of early-life adversity on hippocampal volume; B = effect of hippocampal volume on depression after controlling for early-life adversity; and C′ = direct effect of early-life adversity on depression controlling for hippocampal volume.

Due to the scale differences between coefficients from ordinary least-squares regression and Cox regression, comparable coefficients were calculated by multiplying each coefficient by the standard deviation of the predictor variable and dividing by the standard deviation of the criterion variable.

p ≤ .05;

^**

p ≤ .005;

^***

p ≤ .001.