. Author manuscript; available in PMC: 2010 Apr 29.

Published in final edited form as: Biochem Biophys Res Commun. 2009 Dec 31;392(1):36. doi: 10.1016/j.bbrc.2009.12.143

Table 1.

Effect of Cyr61, sclerostin or Cyr61 plus sclerostin on cellular attachement of Swiss 3T3 cells, migration of HUVEC or proliferation of MC3T3 osteoblasts.

Treatment	Cell Attachment Assay Absorbance at 440 nm, mean (SEM)			Vascular Endothelial Cell Migration Assay # cells migrating into clear area, mean (SEM)	Cell Proliferation Assay Absorbance at 440 nm, mean (SEM)
	# cells plated × 10³				# cells plated × 10³
	4	10	20		0.8	4
Medium	0.41 (0.002)	0.42 (0.003)	0.64 (0.018)	10.3 (2.73)	0.186 (0.003)	0.49 (0.014)
Cyr61	0.46 (0.006)^****	0.45 (0.012)^***	0.94 (0.128)^*	24.7 (3.48)	0.195 (0.003)	0.50 (0.008)
Sclerostin	0.42 (0.004)	0.40 (0.007)	0.85 (0.04)	21.7 (3.53)	0.192 (0.003)	0.53 (0.019)
Cyr61 + Sclerostin	0.43 (0.004)^**	0.44 (0.004)	0.90 (0.105)	30.3 (6.74)^*	0.202 (0.002)^****	0.57 (0.009)^****
VEGF	-	-	-	36.7 (5.04)^**

p<0.05

^**

p<0.02,

^***

p<0.005,

^****

p<0.001.