Fig. 1.

Genotypes for 20 markers surrounding the LRRK2 R1441G mutation. A single ten-marker haplotype (indicated by dark gray shading) was shared by all 29 mutation carriers. Incomplete but significant allele sharing is denoted by light gray shading and the frequency of each shared allele in 170 control chromosomes is displayedinthe lower right-hand margin. In instances in which phase could not be unambiguously determined, both alleles are shown. Disease haplotypes inferred using PHASE are indicated in bold type