. Author manuscript; available in PMC: 2010 Feb 12.

Published in final edited form as: HIV Clin Trials. 2008 Jan–Feb;9(1):61. doi: 10.1310/hct0901-61

Table 1.

Reference IQs, Dosing, and Expected Ranges for Protease Inhibitors

Protease Inhibitor	Reference IQ	Starting Dose (protease inhibitor / ritonavir)	Highest Dose (protease inhibitor / ritonavir)	Expected ranges (ng/mL)
Protease Inhibitor	Reference IQ	Starting Dose (protease inhibitor / ritonavir)	Highest Dose (protease inhibitor / ritonavir)	Lower Limit	Upper Limit
Atazanavir	239	300 mg / 100mg QD	300 mg / 200mg QD	100	2,000
Amprenavir	420	600 mg /100 mg BID	900 mg /200 mg BID	100	4,105
Fos-amprenavir	420	700 mg / 100 mg BID	1400 mg / 100 mg BID	100	4,105
Indinavir	106	800 mg / 100 mg BID	1000 mg / 200 mg BID	100	2,000
Lopinavir	1430	400 mg /100 mg BID	600 mg / 250 mg BID^*	200	10,000
Nelfinavir	350	1250 mg BID	1500 mg / 200 mg BID	200	4,000
Saquinavir	180	1000 mg / 100 mg BID	1400 mg / 100 mg BID	100	2,000
Tipranavir	9823	500 mg / 200 mg BID	750 mg / 200 mg BID	390	48,214

Highest dose for the 200 mg / 50 mg lopinavir / ritonavir tablet formulation (3 tablets given in combination with 100 mg ritonavir BID). Highest dose for the 133 mg / 33 mg lopinavir / ritonavir capsule formulation was 533 mg / 233 mg (4 capsules given in combination with 100 mg ritonavir BID).