Table 2.

Cox proportional hazards analysis of the effects of expression level and subcellular distribution of TDP43 on neuronal survival

Variable	HRa	95% CI	p
TDP43(WT)-EGFP (n = 238)
NCR	0.982	0.969–0.996	0.0122
Cytoplasmic TDP43-EGFP (fluorescence intensity, a.u.)	1.660	1.189–2.317	0.0029
Nuclear TDP43-EGFP (fluorescence intensity, a.u.)	0.972	0.885–1.068	NS
TDP43(A315T)-EGFP (n = 272)
NCR	0.981	0.965–0.998	0.0278
Cytoplasmic TDP43-EGFP (fluorescence intensity, a.u.)	1.346	1.080–1.678	0.0082
Nuclear TDP43-EGFP (fluorescence intensity, a.u.)	0.972	0.872–1.084	NS

CI, Confidence interval; n, number of neurons; NS, not significant (p > 0.05); a.u., arbitrary unit.

^aHR is reported in relation to SD of the NCR or TDP43-EGFP fluorescence intensity.