FIG. 3.

Schematic depicting the pathways by which Nox5 activates eNOS. Co-expression of eNOS and Nox5 increases the activity of eNOS by promoting hsp90 binding. The release of superoxide from within intracellular organelles such as the ER is proposed to occur through chloride channels (Cl⁻) which also facilitate the release of superoxide to the extracellular space. Formation of hydrogen peroxide (H₂O₂) within the cell may also stimulate calcium entry which activates eNOS. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article at www.liebertonline.com/ars).