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. 2009 Nov;11(11):2685–2700. doi: 10.1089/ars.2009.2695

FIG. 6.

FIG. 6.

mGSH control of cardiolipin oxidation. Under normal conditions, mGSH is able to cope with the stress derived from many apoptotic stimuli. However, depletion of mGSH below a certain threshold will compromise ROS detoxification, leading to its accumulation, resulting ultimately in cardiolipin oxidation.