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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: J Nutr Biochem. 2008 Dec 13;20(12):1000. doi: 10.1016/j.jnutbio.2008.09.004

Table 2.

Genes with the most zinc-altered expression levels in HPR-1 cells

GenBank ID Gene Name Ratio of Zinc Treated vs Control in Gene Expression Level
 Major Biological Function
HPR-1
 PC-3
1hr 3hr 6hr 1hr 3hr 6hr
Increased gene expression
NM_006301 Mitogen-activated protein kinase kinase kinase 12 (MAP3K12) 12.14 8.56 2.62 1.09 1.30 −1.51 Protein phosphorylation; Embryogenesis
NM_148172 Phosphatidylethanolamine N-methyltransferase (PEMT) 9.45 4.25 5.00 −1.29 1.12 1.22 Phosphatidylcholine biosynthesis; lipid metabolism
NM_173621 Chromosome 17 open reading frame 44 (C17orf44) 8.42 2.62 1.54 -* -* -* Unclassified
NM_013361 Zinc finger protein 223 (ZNF223) 8.14 5.18 1.32 -1.96 -5.00 -2.25 Transcription factor; KRAB box transcription factor
NM_013313 Yippee-like 1 (Drosophila) (YPEL1) 6.39 5.18 5.42 1.76 −1.03 −4.17 Regulation of cellular morphology
NM_138334 Josephin domain containing 2 (JOSD2) 4.37 5.92 2.79 −1.20 1.59 1.11 Unclassified
NM_032520 N-acetylglucosamine-1-phosphate transferase, gamma subunit (GNPTG) 3.92 6.93 3.26 1.51 1.17 1.05 Transferase
NM_145803 TNF receptor-associated factor 6 (TRAF6) 3.83 5.29 4.60 −2.37 −1.59 1.09 Signal transduction
NM_006538 BCL2-like 11 (apoptosis facilitator) (BCL2L11) 2.88 5.01 4.49 1.54 1.58 2.00 Oncogenesis; Induction of apoptosis
NM_000076 CDK inhibitor 1C (p57, Kip2) (CDKN1C) 1.99 3.13 6.18 2.55 1.61 1.77 Kinase modulator; Select regulatory molecule
Decreased gene expression
NM_152558 IQ motif containing E (IQCE) −12.5 −4.55 −3.03 1.03 −1.42 −1.85 Unclassified
NM_145288 Zinc finger protein 342 (ZNF342) −8.33 −2.70 −3.45 −1.22 −2.88 −2.34 mRNA transcription regulation; Oncogenesis
NM_001452 Forkhead box F2 (FOXF2) −6.67 −3.85 −8.33 -* −1.13 2.82 Developmental processes; Nucleic acid metabolism; mRNA transcription and its regulation
NM_172239 RNA exonuclease 1 homolog (S. cerevisiae)-like 2 (REXO1L2) −6.07 −4.63 −13.78 −3.38 −4.40 −3.71 Nucleic acid binding; Oxidoreductase
NM_152540 Sec1 family domain containing 2 (SCFD2) −5.84 −7.93 −4.42 1.10 −1.71 12.14 Molecular function unclassified
NM_002548 Olfactory receptor, family 1, subfamily D, member 2 (OR1D2) −5.77 −5.26 −8.36 −1.99 −2.42 −7.27 Chemosensory perception; Signal transduction
NM_002429 Matrix metallopeptidase 19 (MMP19) −5.54 −24.01 −6.47 −1.09 −1.64 −1.08 Extracellular matrix; Protease
XM_211291 Chromosome 17 open reading frame 52 (C17orf52) −5.03 −13.16 −9.11 −1.76 −1.10 −1.28 Unclassified
NM_173590 Chromosome 11 open reading frame 36 (C11orf36) −4.08 −6.43 −5.91 −1.11 −1.20 −1.92 Unclassified
NM_019013 Family with sequence similarity 64, member A (FAM64A) −2.75 −5.38 −20.98 −1.91 −1.14 −2.60 Unclassified

NOTE: The genes were listed in a descending order according to the ratio of 1-hour zinc induced expression vs. the control in HPR-1 cells.

Corresponding results in PC-3 cells were listed aside for the comparison.

*

Signal intensities were flagged as unavailable.