Table 5.

Summary of zinc altered oncogenes and tumor suppressor genes

Pathway	Protein	GenBank ID	Gene symbol	Ratio of Gene Expression in the Cells of Zinc Treated vs. Control
				HPR-1			PC-3
				1hr	3hr	6hr	1hr	3hr	6hr
TGF β	BMPR	NM_001204	BMPR2	−1.64	1.01	−1.20	−1.67	−1.39	−4.35
Wnt	SOX	NM_005634	SOX3	1.22	1.11	2.46	−1.69	−2.22	−3.85
		NM_003107	SOX4	1.35	1.15	−1.82	−1.30	−1.43	−2.50
		NM_017508	SOX6	4.50	2.31	2.25	2.86	-*	-*
		NM_006943	SOX12	5.34	1.88	3.00	2.57	−1.37	−2.13
		NM_004189	SOX14	−1.25	2.55	1.95	−2.17	−1.69	−3.13
		NM_022454	SOX17	1.38	1.53	-*	−2.17	−2.56	−2.94
	APC	NM_000038	APC	−1.16	−1.39	−1.72	−1.72	−3.45	−8.33
Ras	Fos	NM_005252	FOS	2.06	−1.09	−1.35	3.10	19.70	13.59
		NM_006732	FOSB	-*	-*	-*	1.48	13.15	3.33
	Jun	NM_002228	JUN	1.47	1.00	−1.30	−1.37	1.08	−1.20
	ILK	NM_004517	ILK	−1.69	−1.61	−2.63	−1.32	−1.06	−1.09
	Integrin	NM_003637	ITGA10	−1.27	1.06	−1.43	1.30	−1.43	−2.70
		NM_002203	ITGA2	−2.38	−1.61	−2.86	−2.27	−1.43	−2.33
		NM_002204	ITGA3	−2.00	−1.41	1.16	−1.85	−2.78	−2.08
		NM_005353	ITGAD	1.31	−2.38	1.65	1.39	3.09	2.31
		NM_000632	ITGAM	1.55	1.30	2.03	−1.52	−1.05	1.62
		NM_002210	ITGAV	−2.00	−2.33	−3.85	−1.25	−1.96	−1.30
		NM_000887	ITGAX	-*	3.44	2.40	−2.38	−1.05	-*
		NM_000211	ITGB2	−2.00	−2.94	−1.89	−1.61	−1.30	−1.49
		NM_000888	ITGB6	-*	−5.00	−2.38	−2.13	−1.04	-*
	NF1	NM_000267	NF1	−1.79	−1.96	−2.56	1.22	−2.78	−3.23
	VHL	NM_000551	VHL	1.08	1.80	1.58	−1.35	−2.27	−1.49
Akt	Akt	NM_005163	AKT1	6.38	2.73	5.00	−1.05	2.02	1.46
	JAK	NM_000215	JAK3	8.40	5.49	2.33	-*	−2.50	−4.00
	PI3K	NM_002645	PIK3C2A	−2.78	−1.59	−5.00	−2.13	−2.04	−3.70
		NM_002647	PIK3C3	1.10	−1.37	−1.19	−1.23	−1.54	−3.33
		NM_003629	PIK3R3	−2.94	−2.70	−2.17	−2.08	−1.35	−1.82
		NM_014308	PIK3R5	3.73	-*	7.18	-*	−1.11	1.35
	TSC1/TSC2	NM_000368	TSC1	1.27	−1.11	−1.85	−2.70	−3.33	−1.79
		NM_000548	TSC2	5.32	1.59	3.67	−1.20	−1.08	−1.22
Hedgehog	Smo	NM_005631	SMO	1.60	3.56	2.33	−2.22	2.29	−1.22
	Cyclin D	NM_053056	CCND1	1.89	3.59	−1.39	−1.28	−1.37	−1.69
	Cyclin E	NM_001238	CCNE1	2.03	−1.01	−1.09	−1.06	−1.41	1.12
		NM_057735	CCNE2	−2.17	−1.96	−3.23	1.07	1.18	−1.61
	CDK2	NM_001798	CDK2	-*	1.02	−1.27	−3.57	−1.08	−2.08
Cell cycle	ARF	NM_001662	ARF5	−1.33	−1.08	−1.85	−1.49	−1.37	−2.13
		NM_001663	ARF6	−1.00	1.25	−2.22	−1.03	−2.63	−2.63
	ATM	NM_000051	ATM	−1.12	−3.33	−4.55	−1.08	−3.03	-*
	ATR	NM_001184	ATR	−1.03	−1.18	−2.00	−2.22	−1.39	−1.69
	BRCA1	NM_007305	BRCA1	1.33	−1.41	−1.33	−1.28	−1.03	−2.50

^*Signal intensities were flagged as unreliable.