Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Repeated intermittent morphine administration-induced mechanical allodynia (A) and thermal hyperalgesia (B). Mice received saline or morphine sulfate (day 1–3: 20 mg/kg; day 4: 40 mg/kg; twice daily, s.c.). The paw withdrawal threshold to von Frey filament probing and withdrawal latency to radiant heat were determined. Data are expressed as mean ± SEM *p < 0.05, **p < 0.01, ***p < 0.001, compared with the saline-treated group; n = 5 for each group.
