Figure 4.

Effect of KN93 on locomotor activity. Mice were trained to remain on a fixed speed (4 rpm) rotarod for 60 s. On the following day, each mouse was retrained to ensure that it could stay on the rotarod for at least 60 s. Baseline was tested by placing the mice on an accelerating rotarod (4–40 rpm over 300 s). The latency to fall from the rotarod was recorded. Mice were then administered with either KN93 (45 nmol), KN92 (45 nmol) or saline intrathecally and retested 0.5, 1, 2, 4 and 8 h later. Neither KN93 nor KN92 significantly impaired locomotor activity. Data are expressed as mean ± SEM p > 0.05, compared with the saline-treated group; n = 5 for each group.