Figure 1.

Salience in outcome (reward magnitude). Brain activation and beta weights in the right VLPFC/anterior insula as found for the interaction of contrasts modelling salience in patients suffering from schizophrenia and controls scanned with the magnitude paradigm. The beta values were extracted from the maximum voxel of the demonstrated activation. The map was thresholded at p < 0.005 at the voxel-level and at an extent threshold of p < 0.05 at the cluster-level. The interaction contrast is masked by the contrast in the controls’ group alone thresholded at p < 0.005 at the voxel-level. The coefficient “a” taken as a measure of the shape of a U-shaped regression curve indicates a more shallow curve the lower the levels and an inverse U-shape with negative values. The values in control subjects were significantly higher than in the patients. r/high, r/low, no, o/low, o/high: receipt of high reward, receipt of low reward, receipt of no reward, omission of low reward, omission of high reward.