Figure 2.

Salience and psychopathology (reward magnitude). In study 1 (index study) and study 2 (replication study) we found significant negative correlations with anhedonia scores (social anhedonia and physical anhedonia, respectively) and the coefficient “a” extracted from the VLPFC where group differences (controls > patients with schizophrenia) were found, that is, lower anhedonia scores predicted a pattern with steeper U-shaped curves as found in the controls. Correlations were significant for the social anhedonia scores (p = 0.04) in all subjects, patients and controls in the index study 1 and for the physical anhedonia scores in study 2 in all subjects (p = 0.03) driven by a significant effect in the patients (p = 0.02). Anhedonia scores were not obtained in three of 16 patients in study 1 and 4 of 12 patients in study 2.