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. Author manuscript; available in PMC: 2010 Feb 12.
Published in final edited form as: J Am Chem Soc. 2007 Sep 27;129(42):12870. doi: 10.1021/ja074432m

Figure 2. Detection of phenylpyrazole (11) provides evidence for the formation of malondialdehyde equivalents in TPZ-damaged DNA.

Figure 2

TPZ-damaged DNA was treated with phenylhydrazine (20 mM) for 15 h to convert base propenals and other malondialdehyde equivalents into phenylpyrazole. The reactions were extracted with hexane, concentrated, and analyzed by GC-MS as described in the Experimental Section.