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. Author manuscript; available in PMC: 2010 Feb 12.
Published in final edited form as: Clin Cancer Res. 2005 May 15;11(10):3743. doi: 10.1158/1078-0432.CCR-04-1990

Fig. 2.

Fig. 2

AdTSTA-FL – mediated activity in vivo. A, AdTSTA-FL – mediated optical signal in LAPC-9 AD and AI (HRPC) tumors. Ten million infectious units of virus were injected i.t. and imaged by optical CCD camera on the specified day postviral injection. Common logarithms of the percentages of the signal at day 4 of AD and AI tumors are plotted in the right panel. B, AR protein in LAPC-9 tumors. Paraffin-fixed, thin tumor sections were stained with anti-AR antibody. C, AdTSTA-FL activity in tumor cell suspension prepared from LAPC-9 AD and AI (HRPC) tumors. Tumor cell suspension was infected with AdTSTA-FL at MOI = 1 and incubated in the presence of 10 μmol/L casodex or 0.1 or 10 nmol/LR1881. The cell lysates were prepared after 2 days and subjected to FL assay and AR Western blot [10 μmol/L casodex (C); 10 nmol/LR1881 (R)]. The activity difference between AI and AD cells in the presence of R1881 was statistically significant (P < 0.01).