Table 2.
Effects of melatonin on patients with GERD group II (n = 9)
| Pretreatment with melatonin | 4 weeks Post treatment with melatonin | 8 weeks Post treatment with melatonin | |
|---|---|---|---|
| Symptoms: | |||
| 1-Heart burn: | |||
| Yes | 7 | 3 (57.1%) | 0 (100%) |
| Duration(months) | 1.3 ± 0.4 | ||
| 2-Epigastric pain: | |||
| Yes | 6 | 3 (50%) | 1 (83%) |
| Duration(months) | 1.4 ± 0.5 | ||
| B)LES Study: | |||
| 1-LES pressure(mmHg) | 10 ± 1.58 | 14.5 ± 1.58a | 20.2 ± 1.56 ab |
| 2-Residual pressure (mmHg) | 0.012 ± 0.52 | 0.2 ± 0.016 | 0.32 ± 0.013a |
| 3-Relaxation duration (seconds) | 6.8 ± 0.12 | 5.9 ± 0.16 a | 5.3 ± 0.12 a |
| 4-Relaxation % | 86 ± 0.87 | 90 ± 0.86 a | 100 ± 0.00 ab |
| C) PH (at 5 cm above the LES): | 2.3 ± 0.36 | 5.2 ± 0.5 a | 6.7 ± 0.65 ab |
| D) BAO (mmol/h) | 24.7 ± 0.5 | 20.1 ± 0.4 a | 16.6 ± 0.6 ab |
| E) Serum Gastrin(pg/ml) | 22.1 ± 3.2 | 27.2 ± 2.3 a | 32.3 ± 2.1 ab |
| D) Melatonin level at day time (pg/ml): | 18.2 ± 5.54 | 28.26 ± 2.26 a | 34.5 ± 2.35 ab |
a: p < 0.05 relative to pretreatment with melatonin
b: p < 0.05 relative to 4 weeks post treatment with melatonin