Table 3.
Effects of omeprazole on patients with GERD Group III (n = 9)
| Pretreatment with omeprazole | 4 weeks Post treatment with omeprazole | 8 weeks Post treatment with omeprazole | |
|---|---|---|---|
| A) Symptoms: | |||
| 1-Heart burn: | |||
| Yes | 7 | 2 (71.4%) | 0 (100%) |
| Duration(months) | 1.2 ± 0.3 | ||
| 2-Epigastric pain: | |||
| Yes | 6 | 2 | 0 |
| Duration(months) | 1.3 ± 0.4 | (66.7%) | (100%) |
| B)LES Study: | |||
| 1-LES pressure(mmHg) | 10.5 ± 2.86 | 10.4 ± 4.05 | 10.5 ± 2.85 |
| 2-Residual pressure (mmHg) | 0.1 ± 0.064 | 0.2 ± 0.15 | 0.1 ± 0.07 |
| 3-Relaxation duration (seconds) | 6.5 ± 2.74 | 6.3 ± 2.7 | 6.3 ± 2.65 |
| 4-Relaxation % | 87.2 ± 0.17 | 87.3 ± 0.25 | 87.1 ± 0.1 |
| C) PH (at 5 cm above the LES): | 2.1 ± 0.38 | 5.9 ± 0.48a | 7.2 ± 0.32ab |
| D) BAO (mmol/h) | 25.1 ± 0.6 | 17.2 ± 0.7a | 11.5 ± 0.6ab |
| E) Serum Gastrin (pg/ml) | 21.5 ± 4.6 | 32.1 ± 2.1a | 35.9 ± 1.8ab |
| D) Melatonin level at day time (pg/ml): | 18.5 ± 3.75 | 19.2 ± 3.47 | 17.9 ± 3.72 |
a: p < 0.05 relative to pretreatment with melatonin
b: p < 0.05 relative to 4 weeks Post treatment with melatonin