Table 4.
Effects of melatonin and omeprazole on patients with GERD group IV (n = 9)
| Pretreatment with melatonin and omeprazole | 4 weeks Post treatment with melatonin and omeprazole | Post 8 weeks treatment with melatonin and omeprazole | |
|---|---|---|---|
| A) Symptoms: | |||
| 1-Heart burn: | |||
| Yes | 8 | 1(87.5%) | 0 (100%) |
| Duration(months) | 1.4 ± 0.4 | ||
| 2-Epigastric pain: | |||
| Yes | 6 | 1(83.3%) | 0 (100%) |
| ration(months) | 1.3 ± 0.4 | ||
| B) LES Study: | |||
| 1-LES pressure(mmHg) | 10.3 ± 1.68 | 14.5 ± 1.26a | 20.5 ± 1.22ab |
| 2-Residual pressure (mmHg) | 0.012 ± 0.44 | 0.21 ± 0.016 | 0.33 ± 0.016a |
| 3-Relaxation duration (seconds) | 6.8 ± 0.16 | 5.8 ± 0.13a | 5.2 ± 0.12a |
| 4-Relaxation % | 85 ± 1.58 | 90 ± 1.23a | 100 ± 0.00ab |
| C) PH (at 5 cm above the LES): | 1.98 ± 0.37 | 6.1 ± 0.55a | 7.5 ± 0.31ab |
| D) BAO (mmol/h) | 24.9 ± 0.7 | 15.8 ± 0.9a | 10.2 ± 0.9ab |
| E) Serum Gastrin (pg/ml) | 21.9 ± 4.7 | 33.6 ± 2.7a | 36.8 ± 2.1ab |
| D) Melatonin level at day time (pg/ml): | 18.3 ± 3.8 | 28.83 ± 1.82a | 34.5 ± 2.35ab |
a: p < 0.05 relative to pretreatment with melatonin
b: p < 0.05 relative to 4 weeks Post treatment with melatonin