Fig. 1.

a Representative study demonstrating the effect of MBG on vascular leakage in a single rat mesentery postcapillary venule. Images shown were obtained prior to the injection (0 min) and at 30 and 60 min after the bolus injection of 200 nM MBG. FITCalbumin extravasation into the extravascular space is virtually complete by 60 min after MBG injection. b Mean values for the effects of MBG on vascular leakage in mesenteric postcapillary venules compared to rats infused with the vehicle (DMSO) only (sham) at 10, 20, 30, 40, 50 and 60 min of observation. Vascular leakage is expressed as the change in fluorescent intensity inside the vessel compared to that outside the vessel. ∗ p < 0.05: n = 5 for sham and n = 7 for MBG.