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ET-1 action on the periaqueductal gray area of the rat. Top panel. ETA receptors ([125I-PD 151252 binding) in the rat brain identified by in vitro autoradiography (from D’Amico et al. 1996). Periaqueductal gray area (PAG) is outlined. Lower panel. Cerebral vessels of the PAG identified by immunohistochemistry (arrows indicate CD31 staining of vessel endothelium, red). (Dashwood unpublished) *indicates the aqueduct. Scale bars = 2.5 mm for the top and 50 µm for the lower panels
